Recently, the World Economic Forum (2022) shows how Colombia ranks 25th globally (among 50 countries), as a result of the considerable increase of the index in the last three years, based on GEM data. This ranking is based on the National Entrepreneurship Context Index (NECI), which ranks countries with the best conditions for entrepreneurship. In other words, despite the social and economic consequences of the pandemic, the average state of all the structural conditions of the environment for entrepreneurial activity has been improving over the last three years. This book, the result of the GEM Colombia team's research in this 2021-2022 version, presents an analysis of various topics that can be addressed from questions that can be asked by stakeholders.